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Repair Stem Cells Fix Broken Jawbones!

Adult Stem Cells fix broken jawbones in Spain


Bone Repair Cells (BRCs) were used in Spain to repair the faces of patients suffering from severe craniofacial defects in 2008 and the 12-month results were released at a conference in China this month (Aug. 2009). The product was developed by what RSCI considers one of the top stem cell companies in America, Aastrom Biosciences. 

Dr. Jose Mendonca, Director of the Head and Neck Surgery Unit of Hospital POLUSA in Lugo, Spain and previously a Clinical and Research Fellow in Oral and Maxillofacial Surgery at the UCLA School of Dentistry, reviewed the results of treatment with BRCs in three patients with craniofacial defects, as follows: 

1-- The first patient was treated for severe mandibular osteoradionecrosis, or osteonecrosis of the jaw caused by radiation, and presented with pathological fracture and complete numbness of the lower lip. At 12 months post-BRC treatment, the patient displayed restored vascular function, new bone formation, fracture consolidation and total recovery of lip numbness. 

2--The second patient was treated for post-traumatic mandibular osteomyelitis and presented with massive bone loss, chronic infection, chronic pain and total impairment of function of both mandibular nerves. At 12 months post-BRC treatment, the patient experienced complete functional nerve recovery and the formation of new bone. 

3-The third patient was treated for iatrogenic massive bone loss in the posterior maxilla and presented with severe oral function impairment. At 12 months post-BRC treatment, the patient had new bone formation in atrophic areas. 

All patients underwent a minor surgery to insert a dental implant into the newly regenerated jaw bone. Eight weeks later, the dental prosthesis (teeth) was attached to the implant completing the treatment objectives with the restoration of oral function. 

"The outcome of these treatments with BRCs has been very satisfactory. We observed early bone formation in the afflicted areas that eventually resulted in complete healing," said Dr. Mendonca. "Unexpected therapeutic results from treatment with BRCs include peripheral nerve regeneration or repair, new skin formation and proliferation in blood vessels in ischemic areas!! 

NOTE from Don Margolis: RSCI knew that this “trial” would succeed, but how well it came out surprised even us, who have seen five years of Repair Stem Cell successes month after month. We look for unexpected side effects---always positive---ever since TheraVitae’s pioneer heart stem cells surprised everyone by improving the patients’ diabetes in one out of six cases. These “side effects” are, well, astonishing. New blood vessels in ischemic areas from a jawbone? Nerve regeneration? New skin? This will take a while to sink in!


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